Insulin-like growth factor-1, growth hormone-dependent insulin-like growth factor-binding protein and growth in children with chronic renal failure
Identifieur interne : 001086 ( Main/Exploration ); précédent : 001085; suivant : 001087Insulin-like growth factor-1, growth hormone-dependent insulin-like growth factor-binding protein and growth in children with chronic renal failure
Auteurs : M. Hodson [Australie] ; Shane Brown [Australie] ; Paul Roy [Australie] ; R. Rosenberg [Australie]Source :
- Pediatric Nephrology [ 0931-041X ] ; 1992-09-01.
Abstract
Abstract: Insulin-like growth factor-binding protein-3 (IGFBP-3) and insulin-like growth factor-1 (IGF-1) levels were measured by specific radioimmunoassays in children with all degrees of chronic renal failure (CRF). Study group 1 comprised 29 children (10 on dialysis) who had been studied one to four times over 2 years to determine whether IGF-1 and IGFBP-3 levels differed from those in age-matched healthy children and to examine the relationship between these levels and heights. IGF-1 and IGFBP-3 levels did not differ from those in normal children. IGF-1 and IGFBP-3 were significantly correlated, increased with pubertal stage in all children and with age in non-dialysis patients. IGF-1, but not IGFBP-3, correlated with age in dialysis patients. There was no correlation between IGF-1 or IGFBP-3 levels (corrected for age) and height standard deviation score (SDS) in either non-dialysis or dialysis patients. Study group 2 comprised 19 children (7 on dialysis) who were studied prospectively for 1–2 years to examine the relationship between IGF-1 and IGFBP-3 levels, growth rates and nutritional parameters. Mean values of IGF-1 and IGFBP-3 (corrected for age) did not change over 1-year periods, while height SDS fell by −0.38 ±0.21 SD/year in dialysis patients and by −0.11 ±0.29 SD/year in non-dialysis patients. No significant correlations were found between IGF-1 or IGFBP-3 levels and growth rates or nutritional parameters. Thus growth retardation in children with CRF is not related to circulating levels of IGF-1 or IGFBP-3.
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DOI: 10.1007/BF00874005
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Hodson</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Paediatrics, Westmead Hospital, 2145, Westmead, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Shane" sort="Brown, Shane" uniqKey="Brown S" first="Shane" last="Brown">Shane Brown</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Endocrinology, Prince of Wales Hospital, 2031, Randwick, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Roy, Paul" sort="Roy, Paul" uniqKey="Roy P" first="Paul" last="Roy">Paul Roy</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Nephrology, Royal Alexandra Hospital for Children, 2050, Camperdown, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Rosenberg, R" sort="Rosenberg, R" uniqKey="Rosenberg R" first="R." last="Rosenberg">R. Rosenberg</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Nephrology, Prince of Wales Children's Hospital, 2031, Randwick, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Pediatric Nephrology</title><title level="j" type="sub">Journal of the International Pediatric Nephrology Association</title><title level="j" type="abbrev">Pediatr Nephrol</title><idno type="ISSN">0931-041X</idno><idno type="eISSN">1432-198X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1992-09-01">1992-09-01</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="433">433</biblScope><biblScope unit="page" to="438">438</biblScope></imprint><idno type="ISSN">0931-041X</idno></series><idno type="istex">1D65777BB2C52B097250457E313C800133A1C104</idno><idno type="DOI">10.1007/BF00874005</idno><idno type="ArticleID">Art12</idno><idno type="ArticleID">BF00874005</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0931-041X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Insulin-like growth factor-binding protein-3 (IGFBP-3) and insulin-like growth factor-1 (IGF-1) levels were measured by specific radioimmunoassays in children with all degrees of chronic renal failure (CRF). Study group 1 comprised 29 children (10 on dialysis) who had been studied one to four times over 2 years to determine whether IGF-1 and IGFBP-3 levels differed from those in age-matched healthy children and to examine the relationship between these levels and heights. IGF-1 and IGFBP-3 levels did not differ from those in normal children. IGF-1 and IGFBP-3 were significantly correlated, increased with pubertal stage in all children and with age in non-dialysis patients. IGF-1, but not IGFBP-3, correlated with age in dialysis patients. There was no correlation between IGF-1 or IGFBP-3 levels (corrected for age) and height standard deviation score (SDS) in either non-dialysis or dialysis patients. Study group 2 comprised 19 children (7 on dialysis) who were studied prospectively for 1–2 years to examine the relationship between IGF-1 and IGFBP-3 levels, growth rates and nutritional parameters. Mean values of IGF-1 and IGFBP-3 (corrected for age) did not change over 1-year periods, while height SDS fell by −0.38 ±0.21 SD/year in dialysis patients and by −0.11 ±0.29 SD/year in non-dialysis patients. No significant correlations were found between IGF-1 or IGFBP-3 levels and growth rates or nutritional parameters. Thus growth retardation in children with CRF is not related to circulating levels of IGF-1 or IGFBP-3.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Hodson, M" sort="Hodson, M" uniqKey="Hodson M" first="M." last="Hodson">M. Hodson</name></noRegion><name sortKey="Brown, Shane" sort="Brown, Shane" uniqKey="Brown S" first="Shane" last="Brown">Shane Brown</name><name sortKey="Rosenberg, R" sort="Rosenberg, R" uniqKey="Rosenberg R" first="R." last="Rosenberg">R. Rosenberg</name><name sortKey="Roy, Paul" sort="Roy, Paul" uniqKey="Roy P" first="Paul" last="Roy">Paul Roy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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